Understanding how molecular, genetic and cellular effects can lead to health or disease. We bring together a diversity of expertise in multi-omics, cell and molecular biology plus clinical studies to investigate a range of pathogenic mechanisms; our aim is to understand disease mechanisms to guide future therapeutic strategies.Theme Lead: Professor Sara Brown Cathy Abbott Research Group Translation factors in neurodevelopmental disorders Luke Boulter Research Group Signalling in Tissue Repair and Cancer Sara Brown Research Group Investigating genetic mechanisms in atopic eczema (and related conditions) – to design better treatments Fraser Collins Research Group Synovial fibroblast biology Yanick Crow Research Group Genetic disorders of human neurological and immune function Cosimo De Bari Research Group Musculoskeletal Health and Rheumatic Diseases Kathy Evans Research Group Neurodegenerative Disorders: Mechanisms and Drug Discovery Rachel Guest Research Group Liver cell plasticity in Biliary Tract Cancer Erika Kague Research Group Molecular and cellular mechanisms in bone health and diseases Roly Megaw Research Group Molecular and cellular mechanisms of Inherited Retinal Dystrophies. Pleasantine Mill Research Group Genetics of Cilia Biology Anke Roelofs Research Group Regenerative Biology of Skeletal Joints Rebekah Tillotson Research Group Mechanistic understanding of chromatinopathies Alexander von Kriegsheim Research Group Network Biology and Proteomics Simon Wilkinson Research Group Autophagy in Tissue Homeostasis and Cancer This article was published on 2026-01-05
