Anke Roelofs Research Group

Regenerative Biology of Skeletal Joints

Dr Anke Roelofs

Senior Lecturer of Joint Regenerative Biology

Contact details

Research in a Nutshell

I am an investigator in the Rheumatology Research Group. Meet our Team and read about our research on our Team page.

My research focusses on the cellular and molecular response of joint tissues to injury and how these tissues repair and remodel or become diseased in arthritis. By using preclinical models of cartilage injury and arthritis, along with genetic cell-lineage tracing and targeting and single-cell omics technologies, we aim to elucidate the origins, identities, regulation and functions of stem and progenitor cells that reside in the joint tissues in adult life, with a focus on the knee. We explore their role in maintaining joint health and facilitating repair, and how they contribute to joint dysfunction and destruction in arthritis.

Key Publications

Collaborations

  • Professor Tonia Vincent, University of Oxford
  • Professor Francesco Dell’Accio, Queen Mary University of London
  • Dr Suzanne Eldridge, Queen Mary University of London
  • Professor Andrew McCaskie, University of Cambridge
  • Professor Karina Wright, Keele University
  • Professor Valerie Speirs, University of Aberdeen
  • Professor Justin Rochford, University of Aberdeen
  • Dr Michael Morgan, University of Aberdeen
  • Prof Thomas Pap, University Hospital Münster
  • Dr Joanna Sherwood, University Hospital Münster
  • Prof Caroline Ospelt, University of Zürich
  • Dr Tristan Maerz, University of Michigan
  • Dr Alexander Knights, Washington University
  • Dr Janja Zupan, University of Ljubljana

Partners and Funders

  • Versus Arthritis
  • Biosplice Therapeutics, Inc.

 

Scientific Themes

Synovial joint biology, stem and progenitor cells, cartilage repair.

Disease Areas

Joint injury and arthritis.

Technology Expertise

Preclinical models of joint injury and osteoarthritis. Genetic cell-lineage tracing. Single-cell omics.

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