About

We use state-of-the-art genetic, epigenetic, genomic, statistical, computational, biological and molecular approaches and apply these in model systems and in clinical studies for systematic investigation of disease mechanisms. With this knowledge, we aim to improve disease prediction, prevention, diagnosis and treatment outcomes. Our research is leading to improved understanding of disease mechanisms, the development of new medicines, the better use of existing medicines and new diagnostic approaches based on genetic knowledge.

At the heart of CGEM strategy is the use of genome and epigenome methods and data to understand how genetic variation between individuals correlates with human traits and disease susceptibility. As well as improving understanding of disease states, a key activity across CGEM is translating our research findings into a clinical setting. Although each of the conditions that we study involves a different gene or gene set, there are important methodological and technical commonalities which unify our research.

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Leadership

CGEM is led by the Centre Director, Professor Tim Aitman, and Section Heads Professor Sara Brown (Section Head of Genetic and Experimental Medicine) and Professor Riccardo Marioni (Section Head of Translational Epidemiology).  The Director and Section Heads are supported by the Centre Executive and key academic and professional services staff (Professor Cathy Abbott, Professor Helen Colhoun, Professor Charlie Lees, Professor Stuart Ralston, Dr Daniel Toddie-Moore, Donna Munro, Susan Anderson).