RNA Synthetic Biology Image Professor Grzegorz Kudla - Wellcome Trust Senior Research Fellow Research in a Nutshell The Kudla lab combines synthetic biology, next-generation sequencing, and computational modelling to study the relationships between RNA sequence, structure, expression, and function. The group focuses on the study of codon usage bias, RNA folding, and RNA interactions. We believe that a detailed understanding of the sequence-function relationship for selected model transcripts will uncover principles applicable to many RNAs. Research Programme Image People Professor Grzegorz Kudla Group Leader Pragya Mittal Research Fellow Fernando Bellido Molías Research Fellow Marcin Plech Research Fellow (with Joe Marsh) Hasan Çubuk PhD student (with Joe Marsh) Jian You Lau Research Assistant Alex McDonnell PhD student Laura Cano Aroca PhD student Mohd Ahmad PhD student Nabid Bhuiyan PhD student Serafina Soehianto MRes student Contact Grzegorz.Kudla@ed.ac.uk Publications Gabryelska et al (2022) Global mapping of RNA homodimers in living cells. Genome Research 32 (5) 956-967 Zhang et al (2021) In vivo structure and dynamics of the SARS-CoV-2 RNA genome. Nature communications 12 (1) Mordstein et al (2020) Codon usage and splicing jointly influence mRNA localization. Cell systems 10 (4) 351-362 Mittal et al. (2018) Codon usage influences fitness through RNA toxicity. Proceedings of the National Academy of Sciences 115 (34) 8639-8644 Ziv et al (2018) COMRADES determines in vivo RNA structures and interactions. Nature methods 15 (10) 785-788 Full publication list can be found on Research Explorer: Grzegorz Kudla — University of Edinburgh Research Explorer Collaborations Professor Laurence Hurst, University of Bath Dr Michael Liss, Thermo Fisher Scientific Professor Eric Miska, University of Cambridge Partners and Funders MRC Michael J Fox Foundation Thermofisher Scientific Themes gene regulation, evolution, RNA, codon usage, synthetic biology This article was published on 2024-09-23
