Andrew Wood Research Group

Research in a Nutshell 

We develop technologies to manipulate the function of genes and proteins in physiological models of human disease, focusing on CRISPR and targeted protein degradation. Our laboratory applies these technologies to study the mechanisms through which the genome is propagated through cell division. Through collaboration, we also apply them more broadly to study other biological processes relevant to human disease.

Our research is divided into three main themes:

1. Degron Tagging
2. Genome Editing
3. Mitotic Chromosome Condensation

1. Krishna et al (2026). Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling. Nature Genetics
2. Taylor et al (2025). Tissue-specific consequences of tag fusions on protein expression in transgenic mice. PLoS Genetics
3. Macdonald et al (2022). Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons eLife
4. Kallimasioti-Pazi et al (2018). Heterochromatin impedes CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair. PLoS Biology
5. Wood AJ et al (2011). Targeted genome editing across species using ZFNs and TALENs. Science.

Full publication list can be found on Research Explorer: Andrew Wood — University of Edinburgh Research Explorer

• Professor Joe Marsh
• Professor Asier Unciti-Broceta
• Professor Roland Wolf
• Professor Gopal Sapkota
• The MRC National Mouse Genetics Network

• The Wellcome Trust
• The Royal Society
• Medical Research Council
• Medical Research Scotland
• Cancer Research Horizons