Andrew Wood Research Group

Research in a Nutshell 

We develop technologies to manipulate the function of genes and proteins in physiological models of human disease, focusing on CRISPR and targeted protein degradation. Our laboratory applies these technologies to study the mechanisms through which the genome is propagated through cell division. Through collaboration, we also apply them more broadly to study other biological processes relevant to human disease.

Our research is divided into three main themes:

1. Degron Tagging
2. Genome Editing
3. Mitotic Chromosome Condensation

Research Programme

Image

Contact

Andrew.J.Wood@ed.ac.uk

Publications

1. Krishna A, Meynert A, Kelder M, Ewing A, Sheraz S, Ferrer-Vaquer A, Grimes G, Becher H, Silk R, Semple C, Kendall T, Hadjantonakis A, Bird T, Marsh JA, Hohenstein P*, Wood AJ*, Ozdemir D* (2025) Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits. Accepted, Nature Genetics. Preprint: 10.1101/2023.11.09.566307v1
2. Taylor G, Macdonald L, Szulc N, Gudauskaite E, Hernandez Moran B, Brisbane JM, Donald M, Taylor E, Zheng D, Gu B, Mill P, Yeyati PL, Pokrzywa W, Ribeiro de Almeida C, Wood AJ. Tissue-specific consequences of tag fusions on protein expression in transgenic mice. PLoS Genetics, 2025 https://doi.org/10.1371/journal.pgen.1011830
3. Macdonald L, Taylor G, Brisbane J, Christodoulou E, Scott L, Von Kriegsheim A, Rossant J, Gu B*, Wood AJ* (2022) Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons. eLife Jun 23, 2022. https://doi.org/10.7554/eLife.77987
4. Kallimasioti-Pazi I, Chathoth K, Taylor G, Meynert A, Ballinger T, Kelder M, Sanli I, Lalevee S, Feil R, Wood AJ. (2018) Heterochromatin impedes CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair. PLoS Biology 16:e2005595
5. ^#Wood AJ, ^#Lo TW, ^#Zeitler B, Pickle CS, Ralston EJ, Lee AH, Amora R, Miller JC, Leung E, Meng X, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Meyer BJ. (2011) Targeted genome editing across species using ZFNs and TALENs. Science. 333:30

* co-senior author, ^#co-first author

Full publication list can be found on Research Explorer: Andrew Wood — University of Edinburgh Research Explorer

Collaborations

• Professor Joe Marsh
• Professor Asier Unciti-Broceta
• Professor Roland Wolf
• Professor Gopal Sapkota
• The MRC National Mouse Genetics Network

Partners and Funders

• The Wellcome Trust
• The Royal Society
• Medical Research Council
• Medical Research Scotland
• Cancer Research Horizons