Biomedical Genomics - Genome integrity and new mutations in health and disease. DNA sequence changes – from single mutations to more complex alterations – can alter the biology of our cells, drive the development of cancer and are responsible for genetic disease. The Biomedical Genomics Theme combines computational, genetic and cellular approaches to understand how and when these changes arise, what effects they have on our cells, how they lead to disease, and influence responses to treatment.Theme Lead: Professor Martin Taylor Tim Aitman Research Group Diagnosis of rare recessive disease by exome sequencing Simon Biddie Research Group Functional and translational genomics group Malcolm Dunlop Research Group Colorectal Cancer, Genetic Susceptibility, Prevention Ailith Ewing Research Group Evolutionary trajectories of structural variation in cancer Susan Farrington Research Group Colorectal Cancer Genetics Charlie Gourley Research Group Nicola Murray Centre for Ovarian Cancer Research Robb Hollis Research Group Molecular defects in ovarian cancer Grzegorz Kudla Research Group RNA Synthetic Biology Joe Marsh Research Group Protein Variant Interpretation Aneta Mikulasova Research Group (Epi)genomic Instability in Multiple Myeloma Colin Semple Research Group Origins and Impacts of Structural Mutations Martin Taylor Research Group Mutagenesis and its Biomedical Impact Joris Veltman Research Group Reproductive genomics and genomic medicine Margot Wyrwoll Research Group Genotype-phenotype correlations in male infertility This article was published on 2026-01-05
