Molecular and genetic mechanisms in atopic eczema Section Head: Genetic and Experimental Medicine Professor Sara Brown Group Leader Contact details Email: sara.brown@ed.ac.uk Research in a NutshellSara is a clinical academic dermatologist, caring for patients of all ages with a wide range of skin diseases. Her research focusses on increasing the understanding of how a person’s genetic make-up predisposes to the inflammatory skin disease atopic eczema and associated systemic conditions. Sara is also an associate member of the Centre for Inflammatory Research https://www.ed.ac.uk/inflammation-research/people/associate-members/prof-sara-brown.The Brown Lab uses a human skin cells to create a skin organoid model which can be precisely manipulated to investigate specific molecular genetic effects. These studies are informed by genome-wide and population-based research with international collaboration. Current and future work tests gene-environment interactions, to address an important question regarding why eczema has increased in prevalence in recent decades.The ultimate aim of Sara’s work is to define targets for the development of new and better treatments for people affected by eczema, dry skin (ichthyoses) and related allergic conditions. Group External Website People NameRole Professor Sara BrownGroup LeaderMartina EliasPostdoctoral Research FellowLuke JohnstonPostdoctoral Research FellowCarla Roca BayerriPostdoctoral Research FellowEllie EarpECAT PhD StudentMichael SongIntercalated Medical StudentSilvia ShenJointly supervised PhD Student Collaborations Ed-SKIN – the Skin Interest Network, University of EdinburghTim Aitman, Centre for Genomic & Experimental Medicine, University of EdinburghWendy Bickmore, MRC Human Genetics Unit, University of EdinburghStuart Forbes, Centre for Regenerative Medicine, University of EdinburghAndrew Baker, Centre for Cardiovascular Science, University of EdinburghMeynert Group, Bioinformatics Analysis Core, University of EdinburghBeverley Hood, Reader, Edinburgh College of Art, University of EdinburghLavinia Paternoster, University of BristolCatherine Smith, Kings College LondonAngus Lamond – University of DundeeNational Phenotypic Screening Centre – University of Dundee Partners and Funders Wellcome Trust - Senior Research Fellowship in Clinical Science & ScotPEN Wellcome Engagement AwardBritish Skin Foundation – large grantBIOMAP consortium (Biomarkers in Atopic Dermatitis and Psoriasis) – funded by the EU Innovative Medicines InitiativeEuropean Lead Factory – ELF/IMI innovative medicines initiativeNIHR HTA award – in collaboration with the University of BristolRosetrees Trust and The Stoneygate Trust – in collaboration with the University of BristolCharles Wolfson Charitable TrustAnonymous philanthropic donors Scientific Themes Genetics, genomics, dermatology, atopic eczema/atopic dermatitis, genetic epidemiology, environment, organoid model, transcriptomics, proteomics This article was published on 2024-09-23