Molecular and genetic mechanisms in atopic eczema Image Professor Sara Brown Section Head: Genetic and Experimental Medicine Research in a Nutshell Sara is a clinical academic dermatologist, caring for patients of all ages with a wide range of skin diseases. Her research focusses on increasing the understanding of how a person’s genetic make-up predisposes to the inflammatory skin disease atopic eczema and associated systemic conditions. Sara is also an associate member of the Centre for Inflammatory Research https://www.ed.ac.uk/inflammation-research/people/associate-members/prof-sara-brown. The Brown Lab uses a human skin cells to create a skin organoid model which can be precisely manipulated to investigate specific molecular genetic effects. These studies are informed by genome-wide and population-based research with international collaboration. Current and future work tests gene-environment interactions, to address an important question regarding why eczema has increased in prevalence in recent decades. The ultimate aim of Sara’s work is to define targets for the development of new and better treatments for people affected by eczema, dry skin (ichthyoses) and related allergic conditions. Brown Lab Website (external) Image People Professor Sara Brown Group Leader Martina Elias Postdoctoral Research Fellow Luke Johnston Postdoctoral Research Fellow Carla Roca Bayerri Postdoctoral Research Fellow Ellie Earp ECAT PhD Student Michael Song Intercalated Medical Student Silvia Shen Jointly supervised PhD Student Contact sara.brown@ed.ac.uk Collaborations Ed-SKIN – the Skin Interest Network, University of Edinburgh Tim Aitman, Centre for Genomic & Experimental Medicine, University of Edinburgh Wendy Bickmore, MRC Human Genetics Unit, University of Edinburgh Stuart Forbes, Centre for Regenerative Medicine, University of Edinburgh Andrew Baker, Centre for Cardiovascular Science, University of Edinburgh Meynert Group, Bioinformatics Analysis Core, University of Edinburgh Beverley Hood, Reader, Edinburgh College of Art, University of Edinburgh Lavinia Paternoster, University of Bristol Catherine Smith, Kings College London Angus Lamond – University of Dundee National Phenotypic Screening Centre – University of Dundee Partners and Funders Wellcome Trust - Senior Research Fellowship in Clinical Science & ScotPEN Wellcome Engagement Award British Skin Foundation – large grant BIOMAP consortium (Biomarkers in Atopic Dermatitis and Psoriasis) – funded by the EU Innovative Medicines Initiative European Lead Factory – ELF/IMI innovative medicines initiative NIHR HTA award – in collaboration with the University of Bristol Rosetrees Trust and The Stoneygate Trust – in collaboration with the University of Bristol Charles Wolfson Charitable Trust Anonymous philanthropic donors Scientific Themes Genetics, genomics, dermatology, atopic eczema/atopic dermatitis, genetic epidemiology, environment, organoid model, transcriptomics, proteomics. This article was published on 2024-09-23
