Cell and Genome Biology

Advancing integrated studies of molecular pathways to understand how genome stability and cellular mechanisms drive health and disease.

Cell and Genome Biology brings together researchers investigating how molecular pathways shape genome stability, nuclear organisation, and cellular function. By integrating expertise in chromatin biology, RNA regulation, developmental processes, and DNA repair, we seek to uncover the fundamental mechanisms that maintain cellular identity and influence human health. Our work spans molecular discovery to disease modelling, using innovative technologies to dissect how disruption of genome function leads to cancer, developmental disorders, and other pathologies. Through collaborative, interdisciplinary research, Cell and Genome Biology aims to generate transformative insights into the molecular foundations of health and the causes of human disease.

Theme Lead: Professor Nick Gilbert

Genetic and Chromosomal Stability in Mammalian Germ Cells

Chromatin Regulators in Cancer

Spatial Organisation of the Human Genome

Chromatin Biochemistry and Epigenetics

RNA processing and gene regulation

Ubiquitin signaling in brain cancer

Mechanism and Regulation of Chromosome Replication

Brain Cancer Survival Pathways

Chromatin Structure and Genome Integrity

Mechanisms for Microcephaly, Cancer and Autoinflammation

Gene Regulation in Human Craniofacial Development and Disease

Mechanisms of establishment, regulation and differentiation of early mammalian lineages in vivo and in vitro

Epigenetics in Human Disease

Genome defence mechanisms