Mutagenesis and its Biomedical Impact Professor Martin Taylor Contact details Email: martin.taylor@ed.ac.uk Research in a Nutshell We study why mutations occur where they do and what effect they have when they arise. Genetic mutations are important, they are responsible for inherited disease, drive the development of cancer, allow bacteria and viruses to escape our drugs and immune system, and provide the raw material for evolution. Most of our research spans our three core aims:1. Understanding mutational processes. What processes go wrong in our cells to create mutations and how damage to our DNA contributes to this. We are especially interested in the mutations that get inherited from one generation to the next, and those that drive the progression to cancer.2. Interpreting genetic variation. Revealing which mutations have an important biological effect and which are less important. This helps genetic diagnosis and matching the cancer treatment to the patient. We are increasingly realising that combinations of mutations are important for how cells grow and the development of cancer. 3. Learning how mutations alter the regulation of our genes. As a community we can work out fairly well when a mutation is likely to alter the function of a protein, we’ve still got a lot to learn about how mutations alter the production of a protein from a gene. Studying the changes through past evolution helps us understand the effect of new mutations of gene regulation. Group External Website People NameRole Professor Martin TaylorGroup Leader | Biomedical Genomcis Section HeadDr Craig AndersonResearch FellowDr Elizabeth CarmichaelResearch FellowJessica CodlingPhD Student (with Dr Michael Nicholson)Kathleen FranciscaVisiting undergraduate (Hong Kong University)James HayesPhD Student (with Dr Michael Nicholson)Oscar JacksonPhD Student (with Professor Liz Patton)Yinghsien LeePhD Student (with Professor Javier Caceres)Moira PasquierPhD Student (with Dr Duncan Sproul)Dr Lana TalmaneResearch FellowZicheng Yu (YC)PhD Student (with Professor Andrew Jackson) Key Publications Anderson CJ, Talmane L, Luft J, Connelly J, Nicholson MD, Verburg JC, Pich O, Campbell S, Giaisi M, Wei PC, Sundaram V, Connor F, Ginno PA, Sasaki T, Gilbert DM; Liver Cancer Evolution Consortium; López-Bigas N, Semple CA ,Odom DT, Aitken SJ, Taylor MS. Strand-resolved mutagenicity of DNA damage and repair. Nature 2024. doi.org/10.1038/s41586-024-07490-1Nicholson MD, Anderson CJ, Odom DT, Aitken SJ, Taylor MS. DNA lesion bypass and the stochastic dynamics of transcription-coupled repair. PNAS. 2024 121 (20) e2403871121. doi/10.1073/pnas.2403871121Ginno PA, Borgers H, Ernst C, Schneider A, Behm M, Aitken SJ, Taylor MS, Odom DT. Single-mitosis dissection of acute and chronic DNA mutagenesis and repair. Nature Genetics. 2024 doi.org/10.1038/s41588-024-01712-yReijns MAM, Parry DA, Williams TC, Nadeu F, Hindshaw RL, Rios Szwed DO, Nicholson MD, Carroll P, Boyle S, Royo R, Cornish AJ, Xiang H, Ridout K, Schuh A, Aden K, Palles C, Campo E, Stankovic T, Taylor MS, Jackson AP. Signatures of TOP1 transcription-associated mutagenesis in cancer and germline. Nature. 2022; 1–9. doi:10.1038/s41586-022-04403-yAitken SJ, Anderson CJ, Connor F, Pich O, Sundaram V, Feig C, Rayner TF, Lukk M, Aitken S, Luft J, Kentepozidou E, Arnedo-Pac C, Beentjes SV, Davies SE, Drews RM, Ewing A, Kaiser VB, Khamseh A, López-Arribillaga E, Redmond AM, Santoyo-Lopez J, Sentís I, Talmane L, Yates AD, Liver Cancer Evolution Consortium, Semple CA, López-Bigas N, Flicek P, Odom DT, Taylor MS. Pervasive lesion segregation shapes cancer genome evolution. Nature. 2020;583: 265–270. doi:10.1038/s41586-020-2435-1Reijns MAM, Kemp H, Ding J, de Procé SM, Jackson AP, Taylor MS. Lagging-strand replication shapes the mutational landscape of the genome. Nature. 2015;518: 502–506. doi:10.1038/nature14183Full publication list can be found on Research Explorer: Martin Taylor — University of Edinburgh Research Explorer Collaborations Dr Sarah Aitken, Yale University, US.Dr Luke Boulter, IGC, Edinburgh, UKProfessor Javier Caceres, IGC, Edinburgh, UKProfessor Giulio Caravagna, University of Trieste, ItalyProfessor Paul Flicek, The Jackson Laboratory, US.Dr Anton Gartner, Institute for Basic Science, South KoreaProfessor Andrew Jackson, IGC, Edinburgh, UKDr Ava Khamseh, IGC & Informatics, Edinburgh, UKProfessor Núria López-Bigas, IRB, Barcelona, SpainDr Michael Nicholson, School of Mathematics, Edinburgh, UKProfessor Duncan Odom, DKFZ, Heidelberg, Germany.Professor Liz Patton, IGC, Edinburgh, UKProfessor Colin Semple, IGC, Edinburgh, UK Partners and Funders MRCFANTOM ConsortiumScottish Genomes Partnership Scientific Themes Understanding mutational processes, Interpretation of genetic variation, The evolution of gene regulation Technology Expertise Computational genomics, high performance computing, detection of mutations, molecular phylogenetics, gene expression analysis, measurement of genetic selection, high throughput sequencing technologies and assays This article was published on 2024-09-23