Research Groups

Using genetics and genomics to diagnose, understand and better treat disease.

Consistent with our mission to use genetics and genomics to understand the mechanisms of disease and inform novel intervention strategies, our research has a broad focus that spans the full spectrum of single gene inherited forms of disease, such as cystic fibrosis, to common causes of ill health in adulthood that also have a genetic component, such as bone and joint disease.

Our research is broadly grouped within two research sections, Genetic and Experimental Medicine and Translational Epidemiology.

Research image

Translation factors in neurodevelopmental disorders

Diagnosis of rare recessive disease by exome sequencing

Genetic Determinants of Bone disease

Bioimage analysis and digital pathology

Development of pulmonary gene therapy approaches to treat cystic fibrosis and other genetic diseases

Molecular and genetic mechanisms in atopic eczema

Diabetes Medical Informatics and Epidemiology

Neurodegenerative Disorders: Mechanisms and Drug Discovery

A family and population based cohort study for research into the genetic, environmental and sociodemographic influences on health over the life-course

Molecular and cellular mechanisms in bone health and diseases

Uncovering the causes of consequences of inflammatory bowel disease by studying the role of genes, the environment, diet and microbiota and their inter-relationships in gut health and disease

Genetics and epigenetics of cognitive ageing

Pathogenesis and management of rheumatic and bone diseases

The genetics of mental health and cognition

Public Health

Genetic disorders of human neurological and immune function

Provide external quality assessment and educational material for end to end genomic testing for laboratories and clinical genetics centres globally to promote good practice, standardisation and patient safety through Genomics Quality Assessment (GenQA).

Systemic Lupus Erythematosis patient observational studies, fatigue management research, interventional pharma led studies.

Translational and clinical aspects of osteoimmunology; osteoporosis pathogenesis and treatment

Examining cellular and circuit dysfunction associated with monogenic forms of autism and intellectual disability

Using genetic discoveries to identify the mechanisms of mental illness and resilience

Methods for molecular and genetic epidemiology, with applications in clinical prediction and personalised medicine.

Respiratory gene therapy. Preclinical large animal safety/efficacy studies

ENT surgeon with an interest in academic medicine

Identification of risk factors, disease processes and new treatments for common genetic disorders

Improving the care and understanding of gout, and exploring the pathogenesis of osteoporosis

Genomic and data science approaches to understanding the pathophysiology of bipolar disorder

Using statistical methods to answer questions on the pathogenesis, progression and treatment of disease.

Tools and capabilities for sharing, accessing and integrating multi-dimensional bioimaging and biomolecular data

From GWAS to function

The integration of human psychiatric neuroimaging with genetics (common and rare variants), epigenetics, and stem cell models, in the context of clinically-relevant research

Quantitative traits in health and disease