David Porteous (Emeritus)

Identification of risk factors, disease processes and new treatments for common genetic disorders

Section: Genomic Medicine

D.Porteous
Emeritus Professor David Porteous

Research in a Nutshell

How do genes (nature) and the environment (nurture) influence our life course and our health? Our lifestyle (exercise, diet, smoking, drinking) have a direct effect, but apart from these few examples it is hard to measure and monitor our environment and draw conclusions about their influence. By contrast, it is now possible to test our genes with great accuracy, all 20,000 of them. This is the idea behind Generation Scotland in which 24,000 participants from 7,000 families are being studied for how their health and that of their relatives relates to their genes and lifestyle. This work is supported by the Edinburgh Wellcome Trust Clinical Research Facility Genetics Core which we set up in 1999 to support all medical researchers asking genetic questions. Generation Scotland is a research platform open to academic and commercial partnerships in health data science. 

Following a £5.1 million award for the Wellcome Trust (2019-2024), we aim to extend the breadth and depth of the Generation Scotland cohort by utilising remote sample and data collection to recruit the next generation (aged 12 and over) and double the cohort in size, using e-HR data linkage to NHS Scotland routine data to establish a richly annotated, longitudinal, life-course cohort.

Research in a Nutshell

 

Generation Scotland
Prof David Porteous' Research Group

People

Emeritus Professor David PorteousPrincipal Investigator
Mr Archie CampbellChief Technology Officer
Ms Robin FlaigChief Operations Officer
Ms Louise HartleyAdministrator and Finance
Ms Rachel EdwardsAdministrator and Communications
Dr Rebecca DawsonRecruitment, Engagement and Communications
Dr Chloe Fawns-RitchieParticipant data collection
Mr Cliff NangleNHS Scotland health record linkage

Contact

david.porteous@ed.ac.uk

 

Video courtesy of Dementias Platform UK www.dementiasplatform.uk

Collaborations

  • Professor Ian Deary, University of Edinburgh 
  • Professor Andrew McIntosh, University of Edinburgh 
  • Dr Kathy Evans, University of Edinburgh
  • Dr Kirsty Millar, University of Edinburgh
  • Dr Pippa Thomson, University of Edinburgh
  • Dr Kristen Nicodemus, University of Edinburgh
  • Dr Riccardo Marioni, University of Edinburgh
  • Dr Richard McCombie, Cold Spring Harbor Laboratories, NY, USA

Partners and Funders

  • UK Medical Research Council
  • Chief Scientist's Office, Scotland
  • Wellcome Trust
  • National Institutes of Mental Health

Scientific Themes

Population health genetics; psychiatric genetics.

Technology Expertise

Genetics and genome science.

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