Cancer impact

Examples of the impact of our researchers onto cancer treatment include:

• contribution to clinical trials that led to a worldwide marketing authorisation of the breast cancer drug lapatinib;
• identification of cost-effective treatment of depression in cancer patients that lead to improved clinical guidelines;
• contributions to improved genetic screening and quantification of genetic risk in colorectal cancer that helped develop new diagnostic tests, improved primary cancer prevention, facilitated genetic counselling and effected clinical guidelines;
• identification of unique clinical phenotype in ovarian cancer (BRCA1/2-deficiency) and development of individualised therapy (also resulting in novel diagnostic-screening recommendations);
• contributions to establishing the role of aspirin as chemopreventive agent in colorectal cancer that resulted in new clinical recommendations;
• contributions to the UK NHS breast cancer screening programme.