Research Groups

Research to understand how our genome works and how changes in DNA influence human health and cause disease.

Genetic and Chromosomal Stability in Mammalian Germ Cells

Chromatin Regulators in Cancer

Spatial Organisation of the Human Genome

Signalling in Tissue Repair and Cancer

RNA processing and gene regulation

High performance algorithms to analyse large and distributed datasets

Diabetes Medical Informatics and Epidemiology

Genetic disorders of human neurological and immune function

Mechanism and Regulation of Chromosome Replication

Evolutionary trajectories of structural variation in cancer

Chromatin Structure and Genome Integrity

Mechanisms for Microcephaly, Cancer and Autoinflammation

Causal Quantitative Cancer Biology and Population Genomics

RNA Synthetic Biology

Gene Regulation in Human Craniofacial Development and Disease

Protein Variant Interpretation

Epigenetic Mechanisms in Development and Disease

Genetics of Cilia Biology

Mechanisms of establishment, regulation and differentiation of early mammalian lineages in vivo and in vitro

Targeting developmental cell states in melanoma

Causal variants and mechanisms in complex traits and diseases

Origins and Impacts of Structural Mutations

Epigenetics in Human Disease

Mutagenesis and its Biomedical Impact

Mechanistic understanding of chromatinopathies

Biomedical Data Science

From GWAS to function

Genome editing and targeted protein degradation

Genome defence mechanisms

Translational genomics in critical illness

Targeted Causal Machine Learning for Population Biomedicine

Genome regulation of lung inflammation, injury and repair

Chromatin Biochemistry and Epigenetics

Colorectal Cancer, Genetic Susceptibility, Prevention

Cellular and Molecular Mechanisms of Tissue Repair and Regeneration

Topology and Viscoelasticity of DNA and Genomes

Human Genetic Disorders of Insulin Action

Understanding Human Complex Trait Variation

Quantitative traits in health and disease