In Vivo Studies of Microglia-glioma Interactions Image Dr Dirk Sieger – The University of Edinburgh Chancellor’s Fellow Research in a NutshellGlioblastoma is the most aggressive malignant brain tumour that cannot be cured by currently available standard therapies. Glioblastomas are recognized by the immune system and subsequently populated by the residential immune cells of the brain, the microglia. Usually microglia survey the brain and react immediately to any abnormalities to protect our brain. Unfortunately, during glioblastoma growth they fail to do so and seem to support tumour growth instead. The reasons for this disastrous behaviour are not fully understood. Importantly, new studies reveal that microglia can be manipulated within the tumour leading to an anti-tumoural activity of these cells.We aim to understand how microglia are controlled within the tumour environment and intend to identify the underlying molecular mechanisms. This is the necessary first step in the development of new therapeutic strategies to activate these immune cells to fight the tumour. Research Programme Image People Dirk SiegerPrincipal Investigator, holder of CRUK Career Establishment Award and UoE Chancellor’s FellowKaty AstellResearch Assistant-Lab ManagerJulie MazzoliniPostdoctoral ResearcherKelda ChiaPhD studentLloyd HamiltonPhD studentGregoire MorisseResearch TechnicianContactdirk.sieger@ed.ac.uk Dirk Sieger - Research Information CollaborationsDr Marina Mione, University of Trento, ItalyDr Steven Pollard, University of Edinburgh, UKDr Paul Brennan, University of Edinburgh, UKDr Asier Unciti-Broceta, University of Edinburgh, UKProf Catherina Becker, University of Edinburgh, UKProf David Lyons, University of Edinburgh, UKPartners and FundersCancer Research UKRoyal SocietyMS SocietyScientific ThemesBrain tumour, Glioblastoma, Microgli, ZebrafishTechnology ExpertiseConfocal microscopy, Live imaging, Image processing, Zebrafish genetics, Xenografts This article was published on 2024-09-23
