Paul Brennan: Brain Tumour

Research Programme

Laboratory Sciences

Defining The Transcriptional And Epigenetic Rewiring That Accompanies Malignant Transformation Of Low Grade Glioma. Brain Tumour Charity. Principal Applicant. £90,000. 2016-17.

Building infrastructure for brain cancer research: from genome editing to drug discovery with new patient-derived cellular models. Cancer Research UK. Co-applicant. (Principal applicant, Dr Steve Pollard, Edinburgh) £3.7 million. 2016-2021

Chromatin proteins as drug targets for glioblastoma. Brain Tumour Charity. Brain Tumour Charity. Co applicant. (Principal Applicant Dr Steve Pollard, Edinburgh) £1,481,356. 2016-2021

Palladium-activated prodrug therapy: a novel focal therapy for localised cancers of unmet need. ESPRC. Co-applicant. (Principal applicant Dr Asier Unciti-Broceta, Edinburgh) £1,074,212. 2016-2021.

Focal Chemotherapy of Glioma by Activation of Anticancer Drugs via Palladium-Functionalized Implants CRUK Pioneer award. Principal applicant. £173,609.83. 2016-2018.

Nucleosome repositioning as a mechanism for cell memory in cancer Transitions. Wellcome Trust. Co-applicant (Principal applicant Vladimir Teif, Exeter) £85,432.00. 2015-2016

Somatic retrotransposition drives neoplastic mutagenesis in glioblastoma mutiforme Co-applicant. (Principal applicant Professor Geoff Faulkner, Mater Medical Research Institute Ltd)  Funder NHMRC Grant 2012-2015

Clinical Sciences

Understanding the diagnostic pathway for brain tumours in adults and its potential impact on clinical care and outcomes. The Brain Tumour Charity. Principal applicant. £266, 670. June 2015-2017.

Novel Sample Preparation for Improved Circulating Tumour DNA Analysis. Chief Scientists Office. Co-applicant. £220,883. May 2015-2018

A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic Chronic Subdural Haematoma (Dex-CSDH trial). NIHR Heath Technology Assessment Programme (Call 13/15). £1,210,656.05. Co-applicant. September 2014-2019

Treatment of poor-grade subarachnoid haemorrhage trial 2 (TOPSAT2). NIHR Efficacy and Mechanism Evaluation. Co-applicant. £1,255,450.00.