Supervisor: Professor Andrew Jackson Our lab works on single gene human disorders with extreme phenotypes, including the smallest people in the world. We are interested in what these conditions can tell us about biological and common disease processes. To do so we use multiscale approaches including biochemistry, informatics, cell biology and animal models to discover new pathways and processes.We have made recent discoveries which link stem cell function with growth and ageing. We are developing cellular models to understand these links, and the mechanism by which stem cell outputs are altered. The PhD will use these models to gain understanding of how organ and body size is controlled, perhaps shedding light into why humans are bigger than mice and how our brains evolved to be so large. As well, this work should shed light on stem cell plasticity, and exhaustion, with translational relevance to regenerative medicine. Andrew Jackson Research Group This article was published on 2024-11-05
