To request a study protocol please contact the study team. Study overview and rationaleGWAS approaches address polygenic inheritance of CRCMendelian dominant CRC syndromes are largely already identified, a new approach is need targeting de novo mutations and recessive allelesThis study sets out to systematically search for recessive and de novo mutations responsible for CRC using whole genome sequencingPutative pathogenic mutations will be validated in large parallel datasets and model systems This article was published on 2024-09-23