Relatives Inclusion/Exclusion Criteria

Quick Guide

Eligibility: Criteria Summary

Parents - Inclusion

• No past or recent diagnosis of colorectal cancer or other cancer relevant to colorectal cancer predisposition for example, endometrial cancer.
• Alive and are contactable within mainland Great Britain and Northern Ireland.
• No known genetic predisposition to the development of colon cancer.
• Able to provide written informed consent for whole genome sequencing and blood biomarkers
• Able provide a blood sample for whole genome sequencing & blood biomarkers or, failing this, a saliva sample may suffice.
• Ascertainment of demographic data, height and weight, drug history and family history of cancers or otherwise.
• Agree to being contacted should confirmatory samples be required and/or results are found to be of clinically significant relevance.

Parents – Exclusion

• The inability to provide informed consent.
• Unable to sample both parents (i.e. one deceased/ no known whereabouts etc)
• Familial CRC/strong family history of colorectal cancer or other relevant cancers.
• Known mutations in colorectal susceptibility genes in family (e.g. APC, MLH1, MSH2, MSH6, PMS2, MUTYH, POLE1, POLD1, SMAD4/BRCA/STK11).